Article

Transcriptional impacts of substance use disorder and HIV on human ventral midbrain neurons and microglia

2025-02-06

Abstract excerpt

For people with HIV (PWH), substance use disorders (SUDs) are a prominent neurological risk factor, and the impacts of both on dopaminergic pathways are a potential point of deleterious convergence. Here, we profile, at single nucleus resolution, the substantia nigra (SN) transcriptomes of 90 postmortem donors in the context of chronic HIV and opioid/cocaine SUD, including 67 prospectively characterized PWH. We re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bb8aa481-c0d6-5f9d-a200-ed0b6167fdab
DOI: 10.1101/2025.02.05.636667

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptional impacts of substance use disorder and HIV on human ventral midbrain neurons and microgliaDOI 10.1101/2025.02.05.636667Read

Multi-omic Characterization of HIV Effects at Single Cell Level across Human Brain RegionsSemantic proximity Read

Neurological impact of HIV/AIDS and substance use alters brain function and structureSemantic proximity Read

Cell-type specific impact of opioid use disorder and HIV on the human forebrain and cerebellumSemantic proximity Read

Single Nucleus Transcriptomics Reveals Pervasive Glial Activation in Opioid Overdose CasesSemantic proximity Read

Opioid-induced transcriptional reprogramming of cerebrospinal fluid immune cells drives neuroinflammation in SIV-infected rhesus macaquesSemantic proximity Read

Central nervous system (CNS) transcriptomic correlates of human immunodeficiency virus (HIV) brain RNA load in HIV-infected individualsSemantic proximity Read

Cocaine Acts Through Sigma-1 to Enhance HIV Infection of MicrogliaSemantic proximity Read

Characterization of the brain virome in human immunodeficiency virus infection and substance use disorderSemantic proximity Read

Dopamine-driven Increase in IL-1β in Myeloid Cells is Mediated by Differential Dopamine Receptor Expression and Exacerbated by HIVSemantic proximity Read

Epigenetic Alterations in the Brain Associated with HIV-1 Infection and Methamphetamine DependenceSemantic proximity Read

Single-nucleus detection of rare HIV-infected cells defines the cellular landscape of HIV persistence in the human brainSemantic proximity Read

A Single Cell Perspective on the Effects of Dopamine in the Regulation of HIV Latency Phenotypes in a Myeloid Cell ModelSemantic proximity Read