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CCRL2 promotes the interferon-γ signaling response in myeloid neoplasms with erythroid differentiation and mutated <i>TP53</i>

2025-02-27

Abstract excerpt

Patients with myeloid neoplasms with loss-of-function TP53 mutations and erythroid differentiation have poor outcomes, and a better understanding of disease biology is required. Upregulation of interferon-γ (IFN-γ) signaling has been associated with acute myeloid leukemia (AML) progression and chemotherapy resistance, but its drivers remain unclear. In this study, we found that the surface receptor C-C motif chem...

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Literature Corpus work
0063cb19-06eb-5836-a919-a5527439eb41
DOI
10.1101/2025.02.21.639304
Open publication

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CCRL2 promotes the interferon-γ signaling response in myeloid neoplasms with erythroid differentiation and mutated <i>TP53</i>DOI 10.1101/2025.02.21.639304
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