Amplified EPOR/JAK2 Genes Define a Unique Subtype of Acute Erythroid Leukemia.

doi:10.1158/2643-3230.BCD-21-0192

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Amplified EPOR/JAK2 Genes Define a Unique Subtype of Acute Erythroid Leukemia.

Blood cancer discovery - 6 Sept 2022

Takeda June, Yoshida Kenichi, Nakagawa Masahiro M, Nannya Yasuhito, Yoda Akinori, Saiki Ryunosuke, Ochi Yotaro, Zhao Lanying, Okuda Rurika, Qi Xingxing, Mori Takuto, Kon Ayana, Chiba Kenichi, Tanaka Hiroko, Shiraishi Yuichi, Kuo Ming-Chung, Kerr Cassandra M, Nagata Yasunobu, Morishita Daisuke, Hiramoto Nobuhiro, Hangaishi Akira, Nakazawa Hideyuki, Ishiyama Ken, Miyano Satoru, Chiba Shigeru, Miyazaki Yasushi, Kitano Toshiyuki, Usuki Kensuke, Sezaki Nobuo, Tsurumi Hisashi, Miyawaki Shuichi, Maciejewski Jaroslaw P, Ishikawa Takayuki, Ohyashiki Kazuma, Ganser Arnold, Heuser Michael, Thol Felicitas, Shih Lee-Yung, Takaori-Kondo Akifumi, Makishima Hideki, Ogawa Seishi

Abstract excerpt

Acute erythroid leukemia (AEL) is a unique subtype of acute myeloid leukemia characterized by prominent erythroid proliferation whose molecular basis is poorly understood. To elucidate the underlying mechanism of erythroid proliferation, we analyzed 121 AEL using whole-genome, whole-exome, and/or targeted-capture sequencing, together with transcriptome analysis of 21 AEL samples. Combining publicly available...

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PMID: 35839275
DOI: 10.1158/2643-3230.BCD-21-0192
PMCID: PMC9894574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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