Genomic and functional impact of Trp53 inactivation in JAK2V617F myeloproliferative neoplasms

Abstract excerpt

<title>Abstract</title> <p>Classical myeloproliferative neoplasms (MPNs) are characterized by the proliferation of myeloid cells and the risk of transformation into myelofibrosis or acute myeloid leukemia (AML) and <italic>TP53</italic> mutations in MPN patients are linked to AML. However, JAK2V617F has been reported to impact the <italic>TP53</italic> response to DNA damage, suggesting potential overlapping role...

Topics

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• Genomics
• Interferon-alpha
• Janus Kinase 2
• Leukemia, Myeloid, Acute
• Mice
• Mutation
• Myeloproliferative Disorders
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

29f533e3-8602-5f48-8e86-bdc90d0dafc7

DOI

10.21203/rs.3.rs-3125791/v1