Article

Hematopoietic p53 loss cell-extrinsically defines an immune infiltrated microenvironment in leukemia and pre-leukemia

2020-03-24

Abstract excerpt

TP53 is the most frequently mutated gene in human cancers. In Acute Myeloid Leukemia (AML) and Clonal Hematopoiesis of Indeterminate Potential (CHIP), it is one of several recurrent genetic alterations. Despite multiple recent therapeutic advances for AML, TP53 mutated AML is associated with resistance to currently approved therapies and thus, a very poor prognosis. Emerging evidence suggests that mutations in T...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c2719456-7fe6-51bb-b4dd-893693b9cf0c
DOI: 10.1101/2020.03.22.002774

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hematopoietic p53 loss cell-extrinsically defines an immune infiltrated microenvironment in leukemia and pre-leukemiaDOI 10.1101/2020.03.22.002774Read

TP53 abnormalities correlate with immune infiltration and are associated with response to flotetuzumab, an investigational immunotherapy, in acute myeloid leukemiaSemantic proximity Read

Somatic TP53 Mutations Drive T and NK Cell Dysfunction in AML and Can be Rescued by Reactivating Wild Type p53Semantic proximity Read

Transcriptional profiling demonstrates altered characteristics of CD8+ cytotoxic T-cells and regulatory T-cells in TP53-mutated acute myeloid leukemia.Semantic proximity Read

Breaking the guardian of the genome: TP53 dysfunction in myeloid neoplasms.Semantic proximity Read

A line in shifting sand: Can we define and target TP53 mutated MDS?Semantic proximity Read

What have we learned about TP53-mutated acute myeloid leukemia?Semantic proximity Read

Genomic and functional impact of Trp53 inactivation in JAK2V617F myeloproliferative neoplasmsSemantic proximity Read

Deciphering TP53 mutant Cancer Evolution with Single-Cell Multi-OmicsSemantic proximity Read

TP53 in Acute Myeloid Leukemia: Molecular Aspects and Patterns of Mutation.Semantic proximity Read

Dysfunctional diversity of p53 proteins in adult acute myeloid leukemia: projections on diagnostic workup and therapy.Semantic proximity Read

Niche-level immune evasion in TP53 mutant AML residual disease revealed by spatial proteomicsSemantic proximity Read

Navigating prognostic stratification and approach to TP53 -mutated myeloid neoplasms.Semantic proximity Read