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STING agonists in combination with epigenetic drugs potentiate ZNFX1-driven inflammatory necroptosis in <i>TP53</i> -mutated AML

2026-07-28

Abstract excerpt

TP53 -mutated acute myeloid leukemia (AML) has dismal outcomes with current treatments and represents a critical unmet need. TP53 -mutated AML is proposed to be susceptible to immunotherapeutic approaches but, to date, there is no established immunotherapy for this sub-group. Expression of stimulator of interferon genes (STING), a key innate immune driver that activates interferon (IFN) signaling, is decreased by...

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Literature Corpus work
da936d89-985d-5886-a321-34b00da47d02
DOI
10.64898/2026.07.27.741029
Open publication

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STING agonists in combination with epigenetic drugs potentiate ZNFX1-driven inflammatory necroptosis in <i>TP53</i> -mutated AMLDOI 10.64898/2026.07.27.741029
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