Article

CXCL8/CXCR2 signaling mediates bone marrow fibrosis and represents a therapeutic target in myelofibrosis

2021-12-10

Abstract excerpt

<h4>SUMMARY</h4> Pro-inflammatory signaling is a hallmark feature of human cancer, including in myeloproliferative neoplasms (MPNs), most notably myelofibrosis (MF). Dysregulated inflammatory signaling contributes to fibrotic progression in MF; however, the individual cytokine mediators elicited by malignant MPN cells to promote collagen-producing fibrosis and disease evolution remain yet to be fully elucidated....

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Literature Corpus work: b17d8f8f-80bc-5f23-8db6-034c57d6d7bc
DOI: 10.1101/2021.12.08.471791

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