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Multi-omics analysis reveals CLEC2A is a leukemia-restricted CART target in KMT2A-rearranged Acute Myeloid Leukemia

2025-10-08

Abstract excerpt

<title>Abstract</title> <p> Outcomes for patients with acute myeloid leukemia (AML) remain unsatisfactory despite intensive chemotherapy and consolidative hematopoietic stem cell transplant. <sup>1-3</sup> Targeted therapies, such as FLT3 inhibitors <sup>4,5</sup> and gemtuzumab ozogamicin, an anti-CD33 antibody-drug conjugate, <sup>6,7</sup> have demonstrated the ability to augment anti-leukemia responses...

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Literature Corpus work
83c175b8-b3b0-570b-a525-1491cf9e8c12
DOI
10.21203/rs.3.rs-7768680/v1
Open publication

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Multi-omics analysis reveals CLEC2A is a leukemia-restricted CART target in KMT2A-rearranged Acute Myeloid LeukemiaDOI 10.21203/rs.3.rs-7768680/v1
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