C-C motif chemokine receptor-like 2 promotes the interferon-γ signaling response in myeloid neoplasms with erythroid differentiation and mutated TP53.

doi:10.3324/haematol.2025.287740

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Article

C-C motif chemokine receptor-like 2 promotes the interferon-γ signaling response in myeloid neoplasms with erythroid differentiation and mutated TP53.

Haematologica - 1 Feb 2026

Naji Nour Sabiha, Pasca Sergiu, Chatzilygeroudi Theodora, Toledano-Sanz Pablo, Rimando Joseph, An Yuju, Hemani Yashvi, Perkins Brandy, Zeng Xinghan, Talbot Conover, Paun Bogdan, Abdulmalik Abdulmuez, Lossos Chen, Boronina Tatianna R, Sinanidis Ilias, Tsakiroglou Panagiotis, Fernandes Priyanka, Esteb Christopher, Ambinder Alexander J, Cole Robert N, Xian Rena, Gojo Ivana, Paul Suman, Levis Mark J, DeZern Amy E, Luznik Leo, Karanika Styliani, Resar Linda S, Jones Richard J, Bunz Frederick, Gondek Lukasz, Arvanitis Marios, Karantanos Theodoros

Abstract excerpt

Patients with myeloid neoplasms with loss-of-function TP53 mutations and erythroid differentiation have poor outcomes, and a better understanding of disease biology is required. Upregulation of interferon-γ (IFN-γ) signaling has been associated with acute myeloid leukemia (AML) progression, selection of TP53 mutated clones and chemotherapy resistance, but its drivers remain unclear. In this study, we found that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40874324
DOI: 10.3324/haematol.2025.287740
PMCID: PMC12862311

Genes

TP53
CCRL2
JAK2
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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