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IFNα2b modulates anti-tumor immune responses involving STAT3-associated dendritic cell dysfunction in JAK2v617f-positive myeloproliferative neoplasms.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Mar 2026

Fang Lijun, Fu Rongfeng, Dong Huan, Zhang Wenhui, Gao Yuchen, Xu Yanmei, Gu Wenjing, Liu Zixuan, Li Huiyuan, Wang Wentian, Pei Xiaolei, Chi Ying, Zhou Yuan, Wei Jun, Wang Ying, Zhang Lei

Abstract excerpt

AIMS: To define JAK2v617f-induced immune alterations, focusing on STAT3-mediated dendritic cell dysfunction, and evaluate whether IFNα2b restores anti-tumor immunity in JAK2v617f-positive myeloproliferative neoplasms. METHODS: Integrated flow cytometry and single-cell RNA sequencing profiled immune landscapes and signaling pathways, while functional assays assessed dendritic cell differentiation, T cell...

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Cell Differentiation
Dendritic Cells
Interferon alpha-2
Janus Kinase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocyte Activation

Myeloproliferative Disorders

STAT3 Transcription Factor

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PMID: 41539239
DOI: 10.1016/j.drup.2026.101352

Genes

STAT3
FGL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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