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Article

Association of the composition of the bone marrow tumor microenvironment in BCR::ABL1-negative myeloproliferative neoplasms with IFN-γ signaling and driver mutations.

Leukemia - 1 Oct 2025

Bauer Marcus, Vaxevanis Christoforos, Jaekel Nadja, Hackl Hubert, Wilfer Andreas, Zoellig Clara, Haemmerle Monika, Müller-Tidow Carsten, Al-Ali Haifa Kathrin, Seliger Barbara, Wickenhauser Claudia

Abstract excerpt

Constitutive JAK/STAT pathway activation is crucial in the pathogenesis of BCR::ABL1-negative myeloproliferative neoplasms (MPN), but has not yet been linked to interferon (IFN)-γ signaling and tumor microenvironment. Human JAK2 V617F-mutated cell lines, 265 bone marrow biopsies (BMB) of two MPN cohorts, and 50 non-neoplastic BMB, revealed an intrinsic activation of IFN-γ signaling, which was confirmed by public...

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Share to Bone Marrow
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fusion Proteins, bcr-abl

Share to Interferon-gamma

Share to Janus Kinase 2

Share to Myeloproliferative Disorders

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Source

Open in PubMed Open full text

Identifiers

PMID: 40764668
DOI: 10.1038/s41375-025-02706-3
PMCID: PMC12463677

Genes

JAK2
ABL1
BCR
CALR
MPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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