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Article

Broad detection of bacterial type III secretion system and flagellin proteins by the human NAIP/NLRC4 inflammasome

27 Nov 2017

Abstract excerpt

Significance Inflammasomes are cytosolic multiprotein complexes that initiate innate immune responses to microbial infection. Inflammasome specificity is determined by cytosolic innate immune sensors, including nucleotide-binding domain, leucine-rich repeat-containing family, apoptosis inhibitory proteins (NAIPs). In mice, which encode seven different NAIPs, individual NAIPs recognize specific components of the...

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PMID: 29180436
DOI: 10.1073/pnas.1710433114

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