Article

KDM6B interacts with nucleo-adhesome components CSRP2 and TGFB1I1 to regulate EMT

2026-08-25

Abstract excerpt

The methyltransferase EZH2 (Enhancer of Zest Homolog 2) and the demethylase KDM6B (Lysine Demethylase 6B) have been associated with epithelial to mesenchymal transition (EMT) and poor prognosis in various cancers. These enzymes methylate and demethylate H3K27me3 and regulate distinct sets of genes controlling EMT induction, despite having opposite catalytic activities. This could be due to their recruitment or the...

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Literature Corpus work: 0021b9c1-3265-5651-8ee4-e78919d89523
DOI: 10.64898/2026.08.24.737021

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