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Article

The Post-translational Modifications of Smurf2 in TGF-β Signaling

7 Jul 2020

Abstract excerpt

Smad ubiquitin regulatory factor 2 (Smurf2), an essential negative regulator of TGF-β signaling, ubiquitinates TGF-β receptors (TβRs) and Smad proteins, inducing their proteasomal degradation. Smurf2 plays crucial roles in regulating TGF-β signaling and maintaining normal cellular functions and tissue homeostasis; dysfunction of Smurf2 triggers abnormal TGF-β signaling in pathological states. Smurf2 has been...

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PMID: 32733916
DOI: 10.3389/fmolb.2020.00128

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