Article
The m6A methyltransferase METTL3 contributes to Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the regulation of JUNB.
Biochemical and biophysical research communications - 26 Mar 2020
Wanna-Udom Sasithorn, Terashima Minoru, Lyu Hanbing, Ishimura Akihiko, Takino Takahisa, Sakari Matomo, Tsukahara Toshifumi, Suzuki Takeshi
Abstract excerpt
N6-Methyladenosine (m6A) is the most common internal chemical modification of mRNAs involved in many pathological processes including various cancers. In this study, we investigated the role of m6A methyltransferase METTL3 in TGF-β-induced epithelial-mesenchymal transition (EMT) of lung cancer cell lines. The expression of METTL3 and m6A RNA modification were increased during TGF-β-induced EMT of A549 and LC2/ad...
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