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Transforming growth factor-β employs HMGA2 to elicit epithelial–mesenchymal transition

10 Jul 2006

Abstract excerpt

Epithelial-mesenchymal transition (EMT) occurs during embryogenesis, carcinoma invasiveness, and metastasis and can be elicited by transforming growth factor-beta (TGF-beta) signaling via intracellular Smad transducers. The molecular mechanisms that control the onset of EMT remain largely unexplored. Transcriptomic analysis revealed that the high mobility group A2 (HMGA2) gene is induced by the Smad pathway...

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PMID: 16831886
DOI: 10.1083/jcb.200512110

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