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Article

PRMT5 methylating Smad4 activates TGF-β signaling and promotes colorectal cancer metastasis

2022-11-11

Abstract excerpt

<title>Abstract</title> <p>Perturbations in transforming growth factor- β (TGF-β) signaling can lead to a plethora of diseases, including cancer. Mutations and posttranslational modifications (PTMs) of the partner of Smad complexes contribute to the dysregulation of TGF-β signaling. Here, we reported a PTM of Smad4, R361 methylation, that was critical for Smad complexes formation and TGF-β signaling activation. T...

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Literature Corpus work
54f6526c-a424-533a-93ea-20b8adf33825
DOI
10.21203/rs.3.rs-2235025/v1
Open publication

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PRMT5 methylating Smad4 activates TGF-β signaling and promotes colorectal cancer metastasisDOI 10.21203/rs.3.rs-2235025/v1
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