Article

EZH2 represses mesenchymal genes and upholds the epithelial state of breast carcinoma cells

2023-03-14

Abstract excerpt

<h4>Summary</h4> Emerging studies support that the Polycomb Repressive Complex 2 (PRC2) regulates phenotypic changes of carcinoma cells by modulating their shifts among metastable states within the epithelial and mesenchymal spectrum. This new role of PRC2 in cancer has been recently proposed to stem from the ability of its catalytic subunit EZH2 to bind and modulate the transcription of mesenchymal genes during...

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Literature Corpus work: a8fae39f-b402-5395-a4e0-597471151fc1
DOI: 10.1101/2023.03.13.532335

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