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UBR7 in concert with EZH2 inhibits the TGF-β signaling leading to extracellular matrix remodeling

25 Jun 2024

Abstract excerpt

The intricate interplay between resident cells and the extracellular matrix (ECM) profoundly influences cancer progression. In triple-negative breast cancer (TNBC), ECM architecture evolves due to the enrichment of lysyl oxidase, fibronectin, and collagen, promoting distant metastasis. Here we uncover a pivotal transcription regulatory mechanism involving the epigenetic regulator UBR7 and histone...

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PMID: 38923455
DOI: 10.1016/j.celrep.2024.114394

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