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Article

Identification of novel Smad2 and Smad3 associated proteins in response to TGF‐β1

26 Aug 2008

Abstract excerpt

Transforming growth factor-beta 1 (TGF-beta1) is an important growth inhibitor of epithelial cells and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to tumorigenesis. TGF-beta1 signals through the TGF-beta type I and type II receptors, and activates the Smad pathway via phosphorylation of Smad2 and Smad3. Since little is known about the selective activation of Smad2...

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PMID: 18729074
DOI: 10.1002/jcb.21860

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