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Article

An EZH2-dependent transcriptional complex promotes aberrant epithelial remodelling after injury

5 Jul 2021

Abstract excerpt

Unveiling the molecular mechanisms of tissue remodelling following injury is imperative to elucidate its regenerative capacity and aberrant repair in disease. Using different omics approaches, we identified enhancer of zester homolog 2 (EZH2) as a key regulator of fibrosis in injured lung epithelium. Epithelial injury drives an enrichment of nuclear transforming growth factor-β-activated kinase 1 (TAK1) that...

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Share to Epigenetics and DNA Methylation
Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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PMID: 34224201
DOI: 10.15252/embr.202152785

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