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Article

Multiple regulators constrain the abundance of Caenorhabditis elegans DLK-1 in ciliated sensory neurons.

G3 (Bethesda, Md.) - 18 Mar 2025

Sun Yue, Zhou Junxiang, Debnath Arunima, Xie Bokun, Wang Zhiping, Jin Yishi

Abstract excerpt

The conserved MAP3K DLKs are widely known for their functions in synapse formation, axonal regeneration and degeneration, and neuronal survival, notably under traumatic injury and chronic disease conditions. In contrast, their roles in other neuronal compartments are much less explored. Through an unbiased forward genetic screening in C. elegans for altered patterns of GFP-tagged DLK-1 expressed from the...

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PMID: 39854273
DOI: 10.1093/g3journal/jkaf004
PMCID: PMC11917482

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