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<i>xbx-4</i> , a homolog of the Joubert syndrome gene FAM149B1, acts via the CCRK and MAK kinase cascade to regulate cilia morphology

2021-05-10

Abstract excerpt

<h4>ABSTRACT</h4> Primary cilia are microtubule (MT)-based organelles that mediate sensory functions in multiple cell types. Disruption of cilia structure or function leads to a diverse collection of diseases termed ciliopathies (1–3). Mutations in the DUF3719 domain-containing protein FAM149B1 have recently been shown to elongate cilia via unknown mechanisms and result in the ciliopathy Joubert syndrome (4). The...

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Literature Corpus work
2e1adf91-a812-5989-9bef-c31b1d63fac0
DOI
10.1101/2021.05.09.443182
Open publication

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<i>xbx-4</i> , a homolog of the Joubert syndrome gene FAM149B1, acts via the CCRK and MAK kinase cascade to regulate cilia morphologyDOI 10.1101/2021.05.09.443182
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