Article

A Conserved Requirement for RME-8/DNAJC13 in Neuronal Autolysosome Reformation

2023-02-28

Abstract excerpt

<h4>ABSTRACT</h4> Autophagosomes fuse with lysosomes, forming autolysosomes that degrade engulfed cargo. To maintain lysosomal capacity, autolysosome reformation (ALR) must regenerate lysosomes from autolysosomes using a membrane tubule-based process. Maintaining lysosomal capacity is required to maintain proteostasis and cellular health, especially in neurons where lysosomal dysfunction has been repeatedly impli...

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Literature Corpus work: a95f2a1b-86f8-5a00-82a8-58acd4feab5e
DOI: 10.1101/2023.02.27.530319

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