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Article

Class II-associated invariant chain peptide-independent binding of invariant chain to class II MHC molecules.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1999

Thayer W P, Ignatowicz L, Weber D A, Jensen P E

Abstract excerpt

The class II-associated invariant chain peptide (CLIP) region of invariant chain (Ii) is believed to play a critical role in the assembly and transport of MHC class II alphabetaIi complexes through its interaction with the class II peptide-binding site. The role of the CLIP sequence was investigated by using mutant Ii molecules with altered affinity for the DR1 peptide-binding site. Both high- and low-affinity...

Topics

Amino Acid Sequence
Animals
Antigens, Differentiation, B-Lymphocyte
Base Sequence
Binding Sites
Biological Transport, Active
COS Cells
DNA Primers
HLA-DR1 Antigen
Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mice

Mutation

Peptide Fragments

Protein Binding

Recombinant Proteins

Solubility

Source

Identifiers

PMID: 9973407

Provenance

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Class II-associated invariant chain peptide-independent binding of invariant chain to class II MHC molecules.PMID 9973407Read ↗

Identification of residues in the class II-associated Ii peptide (CLIP) region of invariant chain that affect efficiency of MHC class II-mediated antigen presentation in an allele-dependent manner.Semantic proximity Read ↗

T cell recognition of flanking residues of murine invariant chain-derived CLIP peptide bound to MHC class II.Semantic proximity Read ↗

Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.Semantic proximity Read ↗

Clip binds to HLA class II using methionine-based, allele-dependent motifs as well as allele-independent supermotifs.Semantic proximity Read ↗

Molecular modeling and design of invariant chain peptides with altered dissociation kinetics from class II MHC.Semantic proximity Read ↗

An altered invariant chain protein with an antigenic peptide in place of CLIP forms SDS-stable complexes with class II alphabeta dimers and facilitates highly efficient peptide loading.Semantic proximity Read ↗

Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP).Semantic proximity Read ↗

In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides.Semantic proximity Read ↗

A novel domain on HLA-DRbeta chain regulates the chaperone role of the invariant chain.Semantic proximity Read ↗

DM-mediated release of a naturally occurring invariant chain degradation intermediate from MHC class II molecules.Semantic proximity Read ↗

A general model of invariant chain association with class II major histocompatibility complex proteins.Semantic proximity Read ↗

Rheumatoid arthritis (RA)-associated HLA-DR alleles form less stable complexes with class II-associated invariant chain peptide than non-RA-associated HLA-DR alleles.Semantic proximity Read ↗

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