Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP).

Abstract excerpt

Invariant chain (Ii) associates with newly synthesized class II molecules in the endoplasmic reticulum (ER), an interaction that has been shown to interfere with peptide binding to class II molecules. The class II-associated invariant chain peptide (CLIP) region (residues 81-104) of Ii is believe...

Topics

• Amino Acid Sequence
• Animals
• Antigens, Differentiation, B-Lymphocyte
• Base Sequence
• Biological Transport
• COS Cells
• Endoplasmic Reticulum
• Genetic Variation
• Golgi Apparatus
• Histocompatibility Antigens Class II
• Major Histocompatibility Complex
• Mice
• Molecular Sequence Data