In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides.

Abstract excerpt

HLA-DR molecules associated with class II-associated invariant chain peptides (CLIP) are generated in vivo as an intermediate in class II maturation. Such complexes can be produced in vitro by proteolytic digestion of DR alpha beta I complexes, suggesting that CLIP is a residual fragment that rem...

Topics

• Alleles
• Amino Acid Sequence
• Antigens, Differentiation, B-Lymphocyte
• Binding Sites
• Cell Line
• Gene Transfer Techniques
• HLA-DR Antigens
• Histocompatibility Antigens Class II
• Molecular Sequence Data
• Mutation
• Protein Binding