Article
Clip binds to HLA class II using methionine-based, allele-dependent motifs as well as allele-independent supermotifs.
Molecular immunology - 1 Sept 1995
Geluk A, Van Meijgaarden K E, Drijfhout J W, Ottenhoff T H
Abstract excerpt
The invariant chain (Ii) region that interacts with class II and inhibits premature peptide binding has been mapped to amino acids 82-107, known as CLIP. It is unclear whether CLIP binds directly to the class II peptide binding groove and thus competitively blocks binding of other peptides, or whether it binds to conserved class II sites and indirectly inhibits peptide binding by inducing conformational changes...
Topics
- Alleles
- Amino Acid Sequence
- Antigens, Differentiation, B-Lymphocyte
- Binding Sites
- Histocompatibility Antigens Class II
- Methionine
- Molecular Sequence Data
- Peptides
- Protein Binding
- Sequence Analysis