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Article

Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.

The Journal of experimental medicine - 1 Feb 1995

Sette A, Southwood S, Miller J, Appella E

Abstract excerpt

Major histocompatibility complex class II-associated invariant chain (Ii) provides several important functions that regulate class II expression and function. One of these is the ability to inhibit class II peptide loading early in biosynthesis. This allows for efficient class II folding and egress from the endoplasmic reticulum, and protects the class II peptide binding site from loading with peptides before...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 7836921
DOI: 10.1084/jem.181.2.677
PMCID: PMC2191868

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.PMID 7836921Read ↗

Identification of residues in the class II-associated Ii peptide (CLIP) region of invariant chain that affect efficiency of MHC class II-mediated antigen presentation in an allele-dependent manner.Semantic proximity Read ↗

Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP).Semantic proximity Read ↗

Clip binds to HLA class II using methionine-based, allele-dependent motifs as well as allele-independent supermotifs.Semantic proximity Read ↗

Promiscuous binding of invariant chain-derived CLIP peptide to distinct HLA-I molecules revealed in leukemic cells.Semantic proximity Read ↗

A general model of invariant chain association with class II major histocompatibility complex proteins.Semantic proximity Read ↗

Posttranslational regulation of I-Ed by affinity for CLIP.Semantic proximity Read ↗

An altered invariant chain protein with an antigenic peptide in place of CLIP forms SDS-stable complexes with class II alphabeta dimers and facilitates highly efficient peptide loading.Semantic proximity Read ↗

I-Ag7 is subject to post-translational chaperoning by CLIP.Semantic proximity Read ↗

Class II-associated invariant chain peptide-independent binding of invariant chain to class II MHC molecules.Semantic proximity Read ↗

T cell recognition of flanking residues of murine invariant chain-derived CLIP peptide bound to MHC class II.Semantic proximity Read ↗

A novel domain on HLA-DRbeta chain regulates the chaperone role of the invariant chain.Semantic proximity Read ↗

Diminished class II-associated Ii peptide binding to the juvenile dermatomyositis HLA-DQ alpha 1*0501/DQ beta 1*0301 molecule.Semantic proximity Read ↗

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