Article
Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.
The Journal of experimental medicine - 1 Feb 1995
Sette A, Southwood S, Miller J, Appella E
Abstract excerpt
Major histocompatibility complex class II-associated invariant chain (Ii) provides several important functions that regulate class II expression and function. One of these is the ability to inhibit class II peptide loading early in biosynthesis. This allows for efficient class II folding and egre...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Antigens, Differentiation, B-Lymphocyte
- Cell Line, Transformed
- Histocompatibility Antigens Class II
- Humans
- Kinetics
- Mice
- Molecular Sequence Data
- Peptides
- Polymorphism, Genetic
- Protein Binding