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Article

T cell recognition of flanking residues of murine invariant chain-derived CLIP peptide bound to MHC class II.

Cellular immunology - 25 Aug 1998

Naujokas M F, Southwood S, Mathies S J, Appella E, Sette A, Miller J

Abstract excerpt

The major site of interaction between MHC class II molecules and invariant chain has been mapped to occupancy of the class II peptide-binding site by the CLIP region of invariant chain. CLIP is also seen as a degradation product of invariant chain and can be found in association with class II as a processing intermediate. Here we analyzed the relative contribution of single amino acids in the murine CLIP (86-102)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 9743557
DOI: 10.1006/cimm.1998.1347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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T cell recognition of flanking residues of murine invariant chain-derived CLIP peptide bound to MHC class II.PMID 9743557Read ↗

Identification of residues in the class II-associated Ii peptide (CLIP) region of invariant chain that affect efficiency of MHC class II-mediated antigen presentation in an allele-dependent manner.Semantic proximity Read ↗

T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates.Semantic proximity Read ↗

Clip binds to HLA class II using methionine-based, allele-dependent motifs as well as allele-independent supermotifs.Semantic proximity Read ↗

Class II-associated invariant chain peptide-independent binding of invariant chain to class II MHC molecules.Semantic proximity Read ↗

A general model of invariant chain association with class II major histocompatibility complex proteins.Semantic proximity Read ↗

Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.Semantic proximity Read ↗

The CLIP-substituted invariant chain efficiently targets an antigenic peptide to HLA class II pathway in L cells.Semantic proximity Read ↗

Promiscuous binding of invariant chain-derived CLIP peptide to distinct HLA-I molecules revealed in leukemic cells.Semantic proximity Read ↗

Molecular modeling and design of invariant chain peptides with altered dissociation kinetics from class II MHC.Semantic proximity Read ↗

Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP).Semantic proximity Read ↗

An altered invariant chain protein with an antigenic peptide in place of CLIP forms SDS-stable complexes with class II alphabeta dimers and facilitates highly efficient peptide loading.Semantic proximity Read ↗

In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides.Semantic proximity Read ↗

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