Article
T cell recognition of flanking residues of murine invariant chain-derived CLIP peptide bound to MHC class II.
Cellular immunology - 25 Aug 1998
Naujokas M F, Southwood S, Mathies S J, Appella E, Sette A, Miller J
Abstract excerpt
The major site of interaction between MHC class II molecules and invariant chain has been mapped to occupancy of the class II peptide-binding site by the CLIP region of invariant chain. CLIP is also seen as a degradation product of invariant chain and can be found in association with class II as a processing intermediate. Here we analyzed the relative contribution of single amino acids in the murine CLIP (86-102)...
Topics
- Alleles
- Amino Acid Substitution
- Animals
- Antigens, Differentiation, B-Lymphocyte
- Epitopes
- Histocompatibility Antigens Class II
- Hybridomas
- Leucine
- Methionine
- Mice
- Mice, Inbred C57BL
- T-Lymphocytes