Article
Regulation of N-formyl peptide receptor signaling and trafficking by individual carboxyl-terminal serine and threonine residues.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2006
Potter Ross M, Maestas Diane C, Cimino Daniel F, Prossnitz Eric R
Abstract excerpt
Adaptation, defined as the diminution of receptor signaling in the presence of continued or repeated stimulation, is critical to cellular function. G protein-coupled receptors (GPCRs) undergo multiple adaptive processes, including desensitization and internalization, through phosphorylation of cytoplasmic serine and threonine residues. However, the relative importance of individual and combined serine and...
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