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Article

Desensitization and internalization of the human motilin receptor is independent of the C-terminal tail.

Peptides - 1 Jul 2008

Mitselos Anna, Peeters Theo L, Depoortere Inge

Abstract excerpt

The motilin receptor (MTLR) is an important therapeutic target for the treatment of hypomotility disorders but desensitization may limit its clinical utility. The aim of this study was to investigate the role of the C-terminal tail of the MTLR in the desensitization, phosphorylation and internalization process. Three MTLR mutants, C-terminally truncated from amino acid 412 till 384 (MTLRDelta385), 374...

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Identifiers

PMID: 18420306
DOI: 10.1016/j.peptides.2008.02.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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