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Article

The CB1 cannabinoid receptor C-terminus regulates receptor desensitization in autaptic hippocampal neurones.

British journal of pharmacology - 1 Apr 2012

Straiker Alex, Wager-Miller Jim, Mackie Ken

Abstract excerpt

BACKGROUND AND PURPOSE: The cannabinoid CB(1) receptor is the chief mediator of the CNS effects of cannabinoids. In cell culture model systems, CB(1) receptors both desensitize and internalize on activation. Previous work suggests that the extreme carboxy-terminus of this receptor regulates internalization via phosphorylation of residues clustered within this region. Mutational analysis of the carboxy-terminus of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22014214
DOI: 10.1111/j.1476-5381.2011.01743.x
PMCID: PMC3423230

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