Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional characterization of human variants of the mu-opioid receptor gene.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jun 2009

Ravindranathan Ajay, Joslyn Geoff, Robertson Margaret, Schuckit Marc A, Whistler Jennifer L, White Raymond L

Abstract excerpt

Opioids and their receptors have an important role in analgesia and alcohol and substance use disorders (ASUD). We have identified several naturally occurring amino acid changing variants of the human mu-opioid receptor (MOR), and assessed the functional consequences of these previously undescribed variants in stably expressing cell lines. Several of these variants had altered trafficking and signaling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analgesics, Opioid
Share to Binding, Competitive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP

Share to Endocytosis

Share to Microscopy, Confocal

Share to Morphine

Share to Receptors, Opioid, mu

Share to Tritium

Source

Open in PubMed Open full text

Identifiers

PMID: 19528663
DOI: 10.1073/pnas.0904509106
PMCID: PMC2705556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional characterization of human variants of the mu-opioid receptor gene.PMID 19528663Read ↗

Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.Semantic proximity Read ↗

Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor.Semantic proximity Read ↗

The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs.Semantic proximity Read ↗

A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling.Semantic proximity Read ↗

A6V polymorphism of the human μ-opioid receptor decreases signalling of morphine and endogenous opioids in vitro.Semantic proximity Read ↗

Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction.Semantic proximity Read ↗

Overview of genetic analysis of human opioid receptors.Semantic proximity Read ↗

Overview of Genetic Analysis of Human Opioid Receptors.Semantic proximity Read ↗

Identification and characterization of six new alternatively spliced variants of the human mu opioid receptor gene, Oprm.Semantic proximity Read ↗

Allelic variation S268P of the human mu-opioid receptor affects both desensitization and G protein coupling.Semantic proximity Read ↗

Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1).Semantic proximity Read ↗

Rescuing the traffic-deficient mutants of rat mu-opioid receptors with hydrophobic ligands.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.