Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rescuing the traffic-deficient mutants of rat mu-opioid receptors with hydrophobic ligands.

Molecular pharmacology - 1 Jul 2003

Chaipatikul Vipa, Erickson-Herbrandson Laurie J, Loh Horace H, Law Ping-Yee

Abstract excerpt

Deletion of a sequence near the fifth transmembrane domain (258RLSKV262, i3-1 mutant) and a motif residing at the proximal carboxyl tail (344KFCTR348, C-2 mutant) resulted in mu-opioid receptor mutants that were poorly expressed on the surface of transfected human embryonic kidney 293 cells. Treatment with the opioid antagonist naloxone, the agonist etorphine, and other hydrophobic ligands enhanced cell surface...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Cyclic AMP
Share to Ligands

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Proteins

Share to Narcotics

Share to Receptors, Opioid, mu

Share to Transfection

Source

Identifiers

PMID: 12815158
DOI: 10.1124/mol.64.1.32

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rescuing the traffic-deficient mutants of rat mu-opioid receptors with hydrophobic ligands.PMID 12815158Read ↗

Inverse agonist up-regulates the constitutively active D3.49(164)Q mutant of the rat mu-opioid receptor by stabilizing the structure and blocking constitutive internalization and down-regulation.Semantic proximity Read ↗

Functional characterization of human variants of the mu-opioid receptor gene.Semantic proximity Read ↗

Replacement of threonine 394 by alanine facilitates internalization and resensitization of the rat mu opioid receptor.Semantic proximity Read ↗

Functional Rescue of Inactivating Mutations of the Human Neurokinin 3 Receptor Using Pharmacological Chaperones.Semantic proximity Read ↗

Naltrexone, Naloxone, Morphine, and Fentanyl Pharmacologically Chaperone a Mutant μ-Opioid Receptor via an Endoplasmic Reticulum Exit Site-Dependent Pathway.Semantic proximity Read ↗

Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal.Semantic proximity Read ↗

Mu-opioid receptor desensitization: role of receptor phosphorylation, internalization, and representation.Semantic proximity Read ↗

Mutational analysis of the structure and function of opioid receptors.Semantic proximity Read ↗

Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid binding cavity.Semantic proximity Read ↗

Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.Semantic proximity Read ↗

Opioid receptor oligomerization. Detection and functional characterization of interacting receptors.Semantic proximity Read ↗

[Mutagenesis study of pharmacological receptors: approach to their structure-function relationships].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.