Article
Differences in patterns of TP53 and KRAS2 mutations in a large series of endometrial carcinomas with or without microsatellite instability.
Cancer - 1 Jan 1999
Swisher E M, Peiffer-Schneider S, Mutch D G, Herzog T J, Rader J S, Elbendary A, Goodfellow P J
Abstract excerpt
BACKGROUND: The correlation between tumor microsatellite instability (MSI) and the accumulation of mutations in KRAS2 and TP53 is uncertain. The authors evaluated the TP53 and KRAS2 genes for mutations in sporadic endometrial carcinomas with microsatellite instability (MSI) and matched MSI negati...
Topics
- DNA Repair
- Endometrial Neoplasms
- Female
- Genes, p53
- Humans
- Microsatellite Repeats
- Mutation
- Polymerase Chain Reaction
- Prognosis
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins p21(ras)
- ras Proteins