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Article

RAS/RAF mutation and defective DNA mismatch repair in endometrial cancers.

American journal of obstetrics and gynecology - 1 Apr 2004

Mutch David G, Powell Matthew A, Mallon Mary Ann, Goodfellow Paul J

Abstract excerpt

OBJECTIVE: Defective DNA mismatch repair is a common genetic abnormality in both colon cancers and endometrial cancers. Cancers with defective DNA mismatch repair have the so-called mutator phenotype and accumulate genetic errors at an increased rate. An early mutational target in cells with defect DNA mismatch repair may be the RAS/RAF pathway. Colon cancers often have KRAS2 mutations and, if not KRAS2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15118616
DOI: 10.1016/j.ajog.2004.01.017

Genes

BRAF
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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