Article
Incidence of microsatellite instability in synchronous tumors of the ovary and endometrium.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2003
Shannon Catherine, Kirk Judy, Barnetson Rebecca, Evans Justin, Schnitzler Margaret, Quinn Michael, Hacker Neville, Crandon Alex, Harnett Paul
Abstract excerpt
PURPOSE: Families with hereditary nonpolyposis colorectal cancer (HNPCC) have an increased lifetime risk of endometrial (40%) and ovarian (10%) carcinomas. Endometrial and ovarian carcinomas from members of these families frequently display a mutator phenotype as manifest by high levels of microsatellite instability (MSI-H). Microsatellite instability (MSI) occurs in 17-32% of sporadic endometrial carcinomas and...
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