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DNA Mismatch Repair Deficiency in Endometrial Carcinoma

1 May 2009

Abstract excerpt

Microsatellite instability (MSI) is the hallmark of a molecular pathway to carcinogenesis due to sporadic or inherited abnormalities of DNA mismatch repair genes. Inherited mutations are seen in hereditary nonpolyposis colorectal cancer syndrome. Endometrial carcinoma shows as high an incidence of MSI as does colorectal carcinoma. This review provides a framework for the gynecologic pathologist to understand the...

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PMID: 19620942
DOI: 10.1097/pgp.0b013e31818d8fe6

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