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Article

Microsatellite instability and mutation analysis of candidate genes in unselected sardinian patients with endometrial carcinoma.

Cancer - 15 Jun 2002

Baldinu Paola, Cossu Antonio, Manca Antonella, Satta Maria P, Pisano Marina, Casula Milena, Dessole Salvatore, Pintus Adriana, Tanda Francesco, Palmieri Giuseppe

Abstract excerpt

BACKGROUND: Microsatellite instability (MSI) is due mostly to a defective DNA mismatch repair (MMR). Inactivation of the two principal MMR genes, hMLH1 and hMSH2, and the PTEN tumor suppressor gene seems to be involved in endometrial tumorigenesis. In this study, Sardinian patients with endometrial carcinoma (EC) were analyzed to assess the prevalence of both the mutator phenotype (as defined by the presence of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12115348
DOI: 10.1002/cncr.10606

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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