Article
Validation of methods for CYP2C9 genotyping: frequencies of mutant alleles in a Swedish population.
Biochemical and biophysical research communications - 27 Jan 1999
Yasar U, Eliasson E, Dahl M L, Johansson I, Ingelman-Sundberg M, Sjöqvist F
Abstract excerpt
Cytochrome P450 2C9 (CYP2C9) catalysis the metabolism of important drugs such as phenytoin, S-warfarin, tolbutamide, losartan, torasemide, and nonsteroidal anti-inflammatory drugs. A functional polymorphism of the CYP2C9 gene has been described. The variant alleles include CYP2C9*2 having a point...
Topics
- Adult
- Aged
- Alleles
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP2C9
- Cytochrome P-450 Enzyme System
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- Middle Aged
- Mutation
- Steroid 16-alpha-Hydroxylase
- Steroid Hydroxylases
- Sweden