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Article

Genetic polymorphisms of CYP2C8 in the Czech Republic.

Genetic testing and molecular biomarkers - 1 Jul 2012

Pechandova Kristina, Buzkova Helena, Matouskova Olga, Perlik Frantisek, Slanar Ondrej

Abstract excerpt

AIM: CYP2C8 represents 7% of the hepatic cytochrome system and metabolizes around 5% of drugs in phase I processes. It also plays a significant role in metabolism of endogenous compounds. More than 20 single-nucleotide polymorphisms (SNPs) have been noted, mainly in exons 3, 5, and 8. The most studied SNPs may lead to decreased enzyme activity and may have impact on drug metabolism. Variant alleles are called...

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Source

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Identifiers

PMID: 22313047
DOI: 10.1089/gtmb.2011.0275
PMCID: PMC3396005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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