Article
Prevalence of CYP2C9 polymorphisms in the south of Europe.
The pharmacogenomics journal - 1 Oct 2009
Sánchez-Diz Paula, Estany-Gestal Ana, Aguirre Carmelo, Blanco Adoración, Carracedo Angel, Ibáñez Luisa, Passiu Marianna, Provezza Lisa, Ramos-Ruiz Ricardo, Ruiz Borja, Salado-Valdivieso Inés, Velasco Eladio A, Figueiras Adolfo
Abstract excerpt
CYP2C9 is a major liver enzyme responsible of the metabolism of many clinically important drugs. The presence of CYP2C9 genetic polymorphisms has been associated with marked interindividual variability in its catalytic activity that could result in drug toxicity. Here we present frequencies of the most common CYP2C9 coding variants CYP2C9*2 (C430T) and CYP2C9*3 (A1075C) in representative samples of four regions...
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