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Article

Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin.

British journal of clinical pharmacology - 1 Sept 1999

Aynacioglu A S, Brockmöller J, Bauer S, Sachse C, Güzelbey P, Ongen Z, Nacak M, Roots I

Abstract excerpt

AIMS: The genetically polymorphic cytochrome P450 enzyme CYP2C9 metabolizes many important drugs. We studied the frequency of the amino acid variants cysteine144 (CYP2C9*2 ) and leucine359 (CYP2C9*3 ) in a Turkish population and the correlation between genotype and phenotype using phenytoin as probe drug. METHODS: CYP2C9 alleles *2 and *3 were measured in 499 unrelated Turkish subjects by PCR and restriction...

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Identifiers

PMID: 10510154
DOI: 10.1046/j.1365-2125.1999.00012.x
PMCID: PMC2014334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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