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Article

Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Iranian population.

Clinical and experimental pharmacology & physiology - 1 Jan 2000

Zand Negin, Tajik Nader, Moghaddam Alireza Salek, Milanian Iraj

Abstract excerpt

1. The genetically polymorphic cytochrome P450 enzymes 2C9 (CYP2C9) and 2C19 (CYP2C19) are involved in the metabolism and elimination of a number of widely used drugs. The polymorphisms give rise to substantial interindividual and interethnic variability in drug excretion rates and final serum concentrations. For this reason, therapeutic responses and adverse drug reactions may vary from one person to another. In...

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Adolescent
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2C9
Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mixed Function Oxygenases

Polymorphism, Genetic

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PMID: 17201743
DOI: 10.1111/j.1440-1681.2007.04538.x

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