Article
Linkage between the CYP2C8 and CYP2C9 genetic polymorphisms.
Biochemical and biophysical research communications - 22 Nov 2002
Yasar Umit, Lundgren Stefan, Eliasson Erik, Bennet Anna, Wiman Björn, de Faire Ulf, Rane Anders
Abstract excerpt
Cytochrome P450 (CYP) 2C8 and 2C9 are polymorphic enzymes. The CYP2C8*3 and CYP2C9*2 are the major variant alleles in Caucasian populations. The enzymes encoded by these variant alleles have impaired function for the metabolism of several drug substrates. In the present study 1468 subjects that were used as population-based controls in the Stockholm Heart Epidemiology Program (SHEEP) were genotyped by allelic...
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