Article
Alternative splicing and hypermutation of a nonproductively rearranged TCR alpha-chain in a T cell hybridoma.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1999
Marshall B, Schulz R, Zhou M, Mellor A
Abstract excerpt
Like Ig genes, TCR genes are formed by somatic rearrangements of noncontiguous genomic V, J, and C regions. Unlike Ig genes, somatic hypermutation of TCR V regions is an infrequent event. We describe the occurrence of spontaneous hypermutation in a nonproductively rearranged TCR alpha-chain gene...
Topics
- Alternative Splicing
- Animals
- Base Sequence
- Cell Separation
- Cloning, Molecular
- Gene Conversion
- Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Hybridomas
- Introns
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Pedigree
- Polymerase Chain Reaction
- RNA-Directed DNA Polymerase
- Receptors, Antigen, T-Cell, alpha-beta