Article
Post-translational attainment of allelic exclusion of the T cell receptor alpha chain in a T cell clone.
International immunology - 1 Jan 1991
Kuida K, Furutani-Seiki M, Saito T, Kishimoto H, Sano K, Tada T
Abstract excerpt
Two in-frame rearranged mouse TCR alpha chain genes from a single CD4+ T cell clone, MS202, specific for self-class II MHC antigen were transfected into a TCR-negative T cell hybridoma together with a beta chain gene derived from the same T cell clone. Both alpha chain genes were efficiently transcribed and translated in the cytoplasm of host cells, but only one alpha chain (V alpha 5) was expressed on the cell...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- CD4 Antigens
- DNA
- Gene Expression
- Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
- Hybridomas
- Mice
- Molecular Sequence Data