Article
On the mechanism of non-allelically excluded V alpha-J alpha T cell receptor secondary rearrangements in a murine T cell lymphoma.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1990
Fondell J D, Marolleau J P, Primi D, Marcu K B
Abstract excerpt
We had previously demonstrated that several subclones derived from a CD3+, CD4-/CD8-, TCR-alpha beta+ murine T cell line have undergone secondary V alpha-J alpha rearrangements at the TCR-alpha locus (1). In an effort to examine the molecular mechanism responsible for these V alpha-J alpha replac...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Northern
- Blotting, Southern
- Chromosome Deletion
- Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
- Genes
- Lymphoma, Non-Hodgkin
- Mice
- Molecular Sequence Data
- RNA, Messenger
- Receptors, Antigen, T-Cell
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocytes
- Transcription, Genetic
- Tumor Cells, Cultured