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Article

Somatic hypermutation in mouse lambda chains.

Immunological reviews - 1 Apr 1998

Azuma T

Abstract excerpt

The frequency and distribution of somatic hypermutation in immunoglobulin genes and the effect of amino acid substitution on the structure/function of antibodies were studied using hybridomas that secrete anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) monoclonal antibodies bearing lambda 1 chains. A high frequency of mutation was observed in V-J exons and J-C introns of rearranged and active lambda 1 chains but not in...

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Identifiers

PMID: 9602356
DOI: 10.1111/j.1600-065x.1998.tb01433.x

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